Skeletal Biology and Disease Modeling in Zebrafish

Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to the phylum Osteichthyes, from which their endoskeletal systems have been inherited. Indeed, and numerous genetically conserved features in terms of skeletal elements, ossification mechanisms, bone matrix components common. Yet differences related morphology function need be considered when investigating zebrafish research. In this review, we focus on architecture emphasis vertebral column associated anatomical structures. We provide an overview different types osseous cells describe composition at microscopic tissue level assessing mineralization. Processes formation also strongly depend loading zebrafish, as elaborate here. Furthermore, illustrate high regenerative capacity bones present some technological advantages using model. highlight axial fin skeleton patterning metabolic disease such after immunosuppressive glucocorticoid treatment, well osteogenesis imperfecta (OI) osteopetrosis research zebrafish. conclude view why larval xenografts powerful tool study metastasis. © 2021 The Authors. Journal Bone Mineral Research published by Wiley Periodicals LLC behalf American Society for (ASBMR).